CordenPharma Latina Facility Capacities

Technologies / Processes

  • Acylation
  • Hydrolysis
  • Wittig
  • Mitsunobu
  • Friedel-Crafts
  • Alkylation
  • Esterification
  • Pd coupling
  • Protection / Deprotection
  • Si-protection / Deprotection
  • Radical based chemistry
  • Dynamic kinetic resolution

Equipment Details

Oral API and Pilot Plant

Reactor Pool
  • 2 x 500 L, 2 x 500 L 3 x 3,000 L, 3 x 4,000 L, 2 x 500 L stainless steel reactors
  • 2 x 6,000 L stainless steel (-80°C to +80°C)
  • 1 x 8,000 L Hastelloy reactor (-80°C to +80°C)
  • 2 x 7,000 L glass-lined reactors (-18°C to +120 °C)
Filtration
  • 2 x 3.9 m2 stainless steel comi-condor centrifuge
  • 1 x 0.54 m2 tumble filter
  • 1 stainless steel niagara plate filter (6 m2)
  • 2 Hastelloy jacketed multi-plate sparkler filters (14 m2)
Drying
  • 1 x comber stainless steel pan dryer (1,700 L)
  • 1 x fluid bed dryer (1,300 L)
  • 1 x turbo ryer


Drug Product Oncology Suite - Oral

Processing equipment
  • Granulation (Zanchetta Roto wet 50L and 600L), Milling (5x) Sieving (2x)
  • Blending (bin, v-blending Bohl, screw mixing PCE)
  • Tableting (Manesty Betapress & Manesty Dry-cota)
  • Capsule (Bosch GKF 800 and 2500; Macofar MT20) with metal detectors
 
Packaging
  • Bottle filling HDPE and glass (King SC 6L; Cremer CF 830/2M)
  • Blistering (Klockner- Hansel CP10L)
  • Packaging (Bosch Cart 5)
 
Labeling and Packaging Development
  • Artwork
  • Package definition
  • Highly flexible (Manual and automated)
  • Technology transfer and project management
 

Drug Product Oncology Suite – Sterile

Processing equipment
  • Dissolution (6x vessels 50-1150L capacity, glass-lined and stainless steel)
  • Vials filling (Prot ST3/D sterilizing tunnel coupled with Farmomac F57 5-102 ml)
  • Freeze dryer (USIFROID De LAMA SMH 3030)
    • Avalable Surface 35,65 m2 (18 shelves)
    • Temperature range on the shelves - 60°C/+50°C
    • SIP at every cycle
Labeling and Packaging Development
  • Artwork
  • Package definition
  • Highly flexible (manual and automated)
  • Technology transfer and project management
 

Drug Product Oral Penicillin

Powder handling
  • Compacting
  • Milling
  • Blending
  • Tablets press (Ronchi)
  • 2 CAPSULES Machines (MATIC 2000/30)
Primary Packaging
  • 2 Oral Suspension lines in plastic bottle (Farmatic, Perfil)
  • 1 Oral Suspension line in glass bottle (Optima)
  • 2 Blisters packaging lines (PARTENA 92, PARTENA 90)
 

Drug Product Sterile Penicillin

Processing equipment
  • Sterile powder filling
  • Washing machine
  • Depirogenating Tunnel
  • Filling/Capping
  • Sealing
  • Washing machine
Labeling and Packaging
  • Dividella multiple packs
  • Farmores B multiple packs
  • HF 77 P large volume vial
Logette single pack
 

Drug Product Oral Cephalosporin

Processing equipment
  • Tablets press (KORSCH)
  • Capsules machine (MATIC 90)
  • Aqueous film coating (GS Pellegrini)
 
Primary Packaging
  • 2 Oral Suspension lines for glass bottles (Optima) and plastic bottles (Acofil)
  • 3 Blisters lines (PARTENA 92, PARTENA 90, FAMAR)
  • 1 Bottling line (King)
 

Drug Product Sterile Cephalosporin

Processing equipment

  • Sterile powder filling
  • Washing machine (LIBRA HYDRA 1800)
  • Depirogenating Tunnel (LIBRA 1250FLS-95-107)
  • Filling/Capping (IMA MD300)
  • Sealing (IMAG 550 8C)
  • Washing machine (LIBRA HYDRA 300)
  • X-ray inspection machine (DYLOG DYXIM 24)
  • Automatic unloading (LIBRA V300)
Labeling and Packaging
  • Single unit packaging line (FREVILLE)
  • Flexible semiautomatic packaging line (CAM AV 78)
  • Multiple units packaging line (FARMORES A)

Capacities

  • 400 m³ reactor capacity, spread over a variety of stainless steel, glass-lined and hastelloy vessels
  • Dedicated production segments for oral and sterile Penicillin and Cephalosporin manufacturing
  • Non-Beta Lactams pilot plant and manufacturing plant

Other Specialties

  • Solvent recovery
  • Thermal oxidizer
  • Incinerator
  • Waste Water Treatment Plant
  • Solid waste management