CordenBioChem Fermentation & Enzymes Platform

Leader in Industrial Large-Scale Fermentation,
Biotechnology, Enzymes & Biocatalysis

   
   
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Platform Description

  • Large-scale Fermentation (3000m³) with single fermenters up to 120m³
  • Full-service from master-cell bank to biocatalysis, including method
    development (both industrial- scale as well as analytics)
CordenBioChem (DE) provides contract development and manufacturing (CDMO) of microbial fermentation, technical enzymes and application of biocatalysis for the synthesis of intermediates and APIs. With fully-controlled facilities, e.g. fermentation using Process Analytical Technology (PAT), CordenBioChem have expertise in development and large-scale production of immobilized enzymes using various carriers.

Beta-Lactam Antibiotics are supplied from CordenPharma Latina (IT) and CordenBiochem (DE) – both dedicated facilities adhering to the latest segregation regulations. 

Being owned by ICIG, the CordenBioChem facility serves as a connection between the synthetic cGMP intermediate manufacturing of CordenPharma and the non-GMP manufacture of intermediates in their sister company, Weylchem.

Platform Capabilities

Fermentation, Enzymes, Biocatalysis & Antibiotics 

Fermentation
  • Large-scale CDMO fermentation
  • Industrialization from feasibility to commercial-scale
  • Cleaning In Place (CIP) and Sanitization In Place (SIP)
  • Dedicated cell bank preparation facility 
Enzymes 
  • Large-scale CDMO enzyme production
  • Broad range of downstream unit operations
  • Enzyme product types:
     
  • ​Whole cell catalysts
  • Stabilized ultrafiltrates
  • Immoblized enzymes
  • Cleaning In Place (CIP) and Sanitization In Place (SIP)


Biocatalysis – “Green Chemistry”


The application of biocatalysis is an essential tool used today in modern chemical synthesis, particularly as it relates to the synthesis of pharmaceutical and fine chemical intermediates and APIs. We apply enzymes on a daily basis in our manufacturing facility and are one of the largest global manufacturers (1’300 MT/year) of a key starting material for Cephalosporin synthesis – namely 7-ACA (enzymatic 7-aminocephalosporanic acid). We have the ability and know-how to scale-up biocatalyis processes to run on commercial scale, as well as produce immobilized enzymes, enzyme concentrates and whole cell catalysts.



Antibiotics
  • 7-ACA (enzymatic 7-aminocephalosporanic acid)
  • Cephalosporins
  • Multi-step API manufacturing & analytical development
ComplianceRegulatory filing in the US, EU, Japan, Canada & Australia




Facilities Included in Platform