LNP Summit 2025: Rational Design of Lipid Nanoparticles for Enabling Extrahepatic Nucleic Acid Delivery
Presented at our LNP Summit Boston – Sept 9 2025
by Dr. Jayesh Kulkarni, Co-Founder & Chief Scientific Officer, NanoVation Therapeutics
Dr. Jayesh Kulkarni shares powerful insights into his team’s work on designing next‑generation LNPs capable of delivering genetic medicines safely and efficiently to extrahepatic tissues, a key frontier for expanding the therapeutic reach of nucleic acid technologies. His session explores:
🔹 A pipeline of novel ionizable lipids tailored for extrahepatic targeting
🔹 Surface modifications to enhance stability, tolerability, and tissue specificity
🔹 How fine‑tuning overall LNP lipid composition drives improved cellular targeting
🔹 Strategies for optimizing LNPs beyond the liver to unlock new therapeutic applications
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