Material Science
Crystallization is crucial for producing high-quality solid materials, influencing attributes like purity and particle size and shape. The choice of the solid form significantly affects drug properties, including solubility and bioavailability, making targeted investigations essential for successful drug product development.
Solid State Centre of Excellence
The CordenPharma Solid State Centre of Excellence specializes in material science and is a dedicated resource of experts serving your projects. It supports the entire CordenPharma facility network for development and manufacturing of APIs and Drug Products, offering tailored services such as crystallization process development, polymorph investigations, and optimal solid form identification.
Our Expertise in Solid State API Support:
- Design and development of crystallization processes for API and intermediates
- Solvent selection, crystallization process strategy, and optimization of purity, yield, and other relevant quality attributes
- Identification of critical parameters for scale-up, definition of filtration, washing, and drying parameters, polymorph control
- Polymorph screening and characterization
- Find the relevant polymorphs and establish the polymorph landscape and transformation scheme
- Salt / co-crystal screening and characterization
- Identify and profile multi-component crystals and rank their suitability for further use. Preformulation activities and support via our bioavailability enhancement services group
- Crystallization as tool to purify materials
- Racemate separation via resolution
- Screening with available bank of chiral reagents, phase-appropriate process development and process characterization
- Solid form characterization, including all relevant characterization techniques, are available at the Solid State Center of Excellence
- IP and CMC support
Want to find out more?
Get in touch with our team of experts to explore bespoke end-to-end CDMO support of your complete drug lifecycle
at any scale.