Oral Peptide Delivery

Various hurdles prevent the absorption of peptides when supplied orally. Strategies to facilitate effective absorption from the gastro-intestinal tract are typically centered around making the peptide more lipophilic, preventing the degradation, and rendering the gastro-intestinal membrane temporarily more permeable.

CordenPharma offers a staged approach to oral peptide delivery, starting with preparation of small-scale samples for oral absorption performance testing, followed by transferring the most successful approach to GMP manufacturing.

CordenPharma provides oral peptide formulation development along the following approaches:

• Increase lipophilicity – Modification of the peptide permeability by means of ion pairing to adjust the lipophilicity. In combination with the use of SMEDDS and LNP carriers, oral bioavailability of peptides can be improved in this approach.
• Reduce degradation – Exploration of peptide degradation and counteraction to prevent degradation.
• Enhance membrane permeability – Use of solid permeation enhancers for the development of oral solid dosage forms by means of classical processes. Here, preformulation aspects of the drug substance and specifics of the permeation enhancer, combined with the appropriate use of formulation technology, leads to user-friendly, convenient, and high-performing tablet type formulations.

As a key player in the peptide field, CordenPharma provides seamless integration from peptidic drug substance to drug product, be it for parenteral or oral application, from first in human support to commercial manufacturing.