Effective Oral Delivery for Peptide-Based Therapeutics
Our decades-long history of peptide drug substance development and supply along with track record of oral solid dosage form development and commercial manufacturing has established a service offering for the oral delivery of peptides that relies on different strategies.
Approaches to Oral Peptide Delivery
One approach we apply to oral peptide formulation is the use of solid permeation enhancers for the development of oral solid dosage forms by means of classical processes. Preformulation aspects of the drug substance and specifics of the permeation enhancer, combined with the appropriate use of formulation technology, leads to user friendly, convenient, and high-performing tablet type formulations.
A second approach involves modification of the peptide permeability by adjusting the lipophilicity by means of ion pairing. Coupled with different methods for delivery (including SMEDDS or LNPs), and measures to prevent gastro-intestinal degradation, these strategies lead to oral dosage forms that deliver peptides across biologic barriers of the gastro-intestinal tract.
As a key player in the peptide field, CordenPharma provides seamless integration from peptidic drug substance to drug product, be it for parenteral or oral application.
Integrated Supply for Peptide-Based Therapeutics
For peptide-based therapeutics, CordenPharma excels with unique end-to-end solutions across our global facility network for the supply of small–, mid– and large-scale peptide drug substance seamlessly integrated with oral solid dosage formulations and robust sterile injectable fill and finish manufacturing.
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