CORDENPHARMA COLORADO FACILITY CAPACITIES

Technologies / Processes

• >> Hydrogenation / Hydrogenolysis
• >> Cryogenic chemistry
• >> Pyrophoric chemistry
• >> Chiral chemistry
• >> Pegylation chemistry
• >> Pre-formulated liquid products
• >> Peptides
• >> Peptide synthesis (10,000 L)
• >> Cyclization (up to 12,000 L)
• >> De-aggregation chemistry (Pseudoprolines, DMB)
• >> Ion exchange (size exclusion chromatography)
• >> Ultrafiltration, Diafiltration, TFF
• >> Precipitation of peptides (allows larger batches)
• >> High & Mid Pressure preparative chromatography
• >> Lab equipment design (mimics plant design)
• >> Special low endotoxin / bioburden engineering setup for oligo manufacturing
• >> PAT (oligo manufacturing)

Equipment Details

• >> Large-scale
• >> Pilot plant
• >> Peptide purification (up to 100 cm column)
• >> Highly active compounds
• >> Extremely large tank farm

Capacities

• >> One of the largest vessel capacities in the API Contract Manufacturing arena
• >> Nearly 470,000 L vessel volume available

Capacities

• >> Enfuvirtide
• >> Valcyte
• >> Cytovene
• >> Linaclotide
• >> Rocaltrol
• >> Highly Active Peptide A
• >> Protease Inhibitor Intermediate